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Cornea and anterior segment in cases using α1-adrenergic receptor antagonists
Pelin Kiyat1, Turgay Turan2, Melis Palamar31Department of Ophthalmology, İzmir Democracy University, Faculty of Medicine, Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkiye2Department of Urology, İzmir Democracy University, Faculty of Medicine, Buca Seyfi Demirsoy Training and Research Hospital, Izmir, Turkiye
3Department of Ophthalmology, Ege University, Faculty of Medicine, Izmir, Turkiye
PURPOSE: The purpose is to evaluate anterior segment parameters using Pentacam Scheimpflug camera system in patients using α1-adrenergic receptor antagonists for benign prostatic hyperplasia (BPH).
METHODS: In this cross-sectional study, 102 left eyes of patients receiving α1-adrenergic receptor antagonists for BPH were compared with 102 age- and gender-matched healthy controls. Anterior segment parameters were measured using Pentacam Scheimpflug camera system under standardized dark conditions. Parameters included are central corneal thickness, corneal volume, anterior chamber depth, anterior chamber volume, anterior chamber angle width, and pupil diameter.
RESULTS: The mean age was 62.7±7.1 years in the treatment group and 62.1±7.8 years in controls (p=0.781). Mean duration of drug use was 16.98±16.3 months (range: 6–60). Anterior chamber depth (p=0.045), anterior chamber volume (p=0.018), anterior chamber angle width (p=0.038), and pupil diameter (p=0.024) were significantly lower in the treatment group compared to controls. No significant differences were found in central corneal thickness (p=0.812) or corneal volume (p=0.165).
CONCLUSION: α1-adrenergic receptor antagonist use is associated with significant changes in anterior segment parameters, especially causing a decrease in anterior chamber parameter values and pupil diameter. These findings may help to predict intraoperative floppy iris syndrome risk and highlight the importance of regular glaucoma screening in these patients.
Manuscript Language: English
