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Oral paracetamol: Evaluation of its effects on intraocular pressure, anterior segment parameters, and axial length
Levent Dogan1, Zeki Baysal1, Omer Ozer1, Esra Celik Karbancioglu2, Ibrahim Edhem Yilmaz31Department of Ophthalmology, Omer Halisdemir University Faculty of Medicine, Nigde, Turkiye2Department of Physical Medicine and Rehabilitation, Omer Halisdemir University Faculty of Medicine, Nigde, Turkiye
3Department of Ophthalmology, Gaziantep Islam Science and Technology University, Gaziantep, Turkiye
PURPOSE: The purpose of the study is to evaluate the effect of oral paracetamol on the intraocular pressure (IOP) and the anterior segment parameters and axial length (AL) in participants without glaucoma.
METHODS: The study involved and evaluated two groups of participants: Group 1, which received oral paracetamol (1 g/day) for 14 days, and Group 2, which received topical brinzolamide (1%, bid) for the same duration. The IOP was measured with a Goldmann applanation tonometer. The central corneal thickness (CCT) and anterior chamber angle (ACA) measurements were performed using a Scheimpflug camera–Placido disc device (Sirius, CSO, Italy). The anterior chamber depth (ACD) and AL measurements were performed using the IOL Master 500 (Carl Zeiss Meditec, Jena, Germany). Measurements were taken before the beginning of oral paracetamol and topical brinzolamide therapy, and 7 and 14 days after the beginning of therapy.
RESULTS: A significant decrease in IOP was observed in both groups at the end of the 1st week (3.5±0.44 mmHg and 3.5±0.39 mmHg in groups 1 and 2, respectively), and no significant difference was found between the groups (p=0.798). The decrease in IOP persisted in the 2nd week, but the reduction was significantly greater in Group 2 (p<0.001). While Group 1 demonstrated a significant decrease in ACD at the end of the 1st week (p=0.005), no significant difference was found at the 2nd week (p=0.101). The AL, ACA, and CCT measurements did not show any significant changes from baseline in both groups (p>0.05, for all comparisons).
CONCLUSION: The findings of this study suggest that paracetamol treatment may have a lowering effect on IOP, although its efficacy may diminish over the weeks. However, further research enrolling glaucoma patients and employing a prolonged treatment period is necessary to delineate the potential role of paracetamol in glaucoma management.
Keywords: Anterior chamber depth, axial length, glaucoma, brinzolamide, intraocular pressure, paracetamol.
Manuscript Language: English
