The aim of this study was to assess the efficacy of sutureless amniotic membrane (AM) technique using a symblepharon ring-AM patch on the persistent epithelial defects and resistant to medical treatment. Two patients to whom an AM patch was applied to the ocular surface using a polymethyl methacrylate symblepharon ring due to corneal surface disorders are evaluated. The implantation of ring-AM was not complicated. Irritation and epithelial defect decreased in both cases. Eventually, vascularized leukoma developed. Ring-AM implantation is a non-invasive and easy procedure in the treatment of ocular surface disease. Ring-AM is an effective and safe biologic bandage in patients, who refuse surgical procedure or to whom surgery is contraindicated due to systemic diseases.Keywords: Amniotic membrane, corneal epithelial defects, symblepharon ring.