To present a pediatric patient with unilateral limbal stem cell deficiency (LSCD) after acetone burn, managed by simple stem cell transplantation simple limbal epithelial transplantation (SLET) surgery and to review the literature on limbal stem cell transplantation techniques. A 12-year-old boy was admitted to the emergency department for acetone burn on his left eye. Following acute management of the chemical injury and amniotic membrane transplantation, the cornea healed with extensive conjunctivalization. He suffered severe photophobia and visual acuity (VA) loss up to 0.16 Snellen lines. Because of severe clinical findings of LSCD, SLET surgery was performed. He had dramatic improvement in corneal epithelialization, stromal transparency, and disappearance of photophobia 2 weeks after the surgery. At 1 year postoperatively, his VA was 0.7 with a stable epithelial surface and minimal corneal haze and he had returned to normal life. SLET is a viable alternative technique in the management of unilateral LSCD and should be present in the armamentarium of all corneal surgeons.Keywords: Chemical eye injury, limbal stem cell deficiency; simple limbal epithelial transplantation.