PURPOSE: The purpose of the study was to evaluate changes in vision and the optical performance of the cornea in patients with keratoconus following treatment with accelerated corneal crosslinking (CXL).
METHODS: Sixty-two eyes of 40 keratoconus patients with 12-month follow-up of after accelerated CXL (9 mw, 10 min) were included in the study. Best-corrected visual acuities (BCVAs), follow-up time, simulated keratometry values, spherical equivalent (SE), manifest astigmatic correction (MAC), total root mean square (RMS), low order aberrations (LOA)-RMS, high-order aberrations (HOAs)-RMS, horizontal coma, vertical coma, horizontal trefoil, vertical trefoil, spherical aberration, thinnest pachymetry (thin), and central corneal thickness values before and after the treatment were reviewed retrospectively. The patients were divided into two groups as those with maximum keratometry values below 51 D (Group 1) and above 51 D (Group 2).
RESULTS: In Group 1, the improvement in BCVA was not significant (p=0.09) but the improvement in Kmax (p=0.001) and SE (p=0.001) was significant. In Group 2, mean BCVA showed improvement of three lines from 0.78±0.5 to 0.48±0.48 logMAR (p=0.016). In addition, the mean Kmax flattened by 0.52 D (p=0.016). SE decreased up (p=0.001) and the improvement in RMS HOA was significant (p=0.005) in Group 2. In Group 1, change in BCVA was correlated with change in SE and spherical aberration (p<0.05, for all). In Group 2, the change in BCVA has significant association with the change in MAC, total RMS HOA, vertical coma, vertical trefoil, and spherical aberrations (p<0.05, for all).
CONCLUSION: Accelerated CXL leads to visual, refractive, topographic, and HOAs improvement, particularly in severe keratoconus.