Should all macular edema be treated with intravitreal injection? Importance of fundus fluorescein angiography in macular edema

Macular edema (ME) is a common entity that can accompany a wide range of diseases. Diagnosing the underlying cause of ME is therefore of great importance. We present two cases of persistent ME. The first patient was a 43-year-old female and the other was a 31-year-old male. Both patients were diagnosed with ME before applying to our clinic and were treated with intravitreal anti-VEGF injections. Detailed examination revealed vitritis and fundus fluorescein angiography showed vasculitic leakage in both patients. The patients were diagnosed as uveitic ME and treated accordingly. Moreover, the second patient was diagnosed with Behçet’s disease in a very short time. Multimodal imaging and detailed examination are crucial in handling of patients with ME. Especially in young patients, uveitis and vasculitis should be suspected.