Eur Eye Res. Ahead of Print: EER-95530 | DOI: 10.14744/eer.2024.95530

Quantitative assessment of the parafoveal vessel density and ganglion cell inner plexiform layer thickness in nonproliferative macular telangiectasia type 2

Aylin Karalezli¹, Cansu Kaya¹, Sema Kaderli², Ahmet KADERLݹ, sabahattin sul^1
1Mugla Sitki Kocman University, Ophthalmology department
²Mugla Education and Research Hospital, Ophthalmology department

PURPOSE: To evaluate the vessel densities (VD) and ganglion cell inner plexiform layer (GCIPL) thicknesses in macular telangiectasia (MacTel) type 2.
METHODS: 36 eyes with MacTel type 2 and 30 controls were included in this prospective study. Based on the presence of ellipsoid zone (EZ) disruption two groups were formed: Group 1, MacTel eyes with intact EZ. Group 2; with EZ disruption.
RESULTS: In all MacTel eyes, a decrease was obtained in VDs and temporal parafoveal thickness at first year. (For group 1 p=0.006, p=0.045. For group 2 p=0.002, p= 0.02) The average and minimum GCIPL also decreased in group 2. (For average p=0.005, for minimum p=0.003) The mean VD, temporal and nasal thicknesses, average minimum GCIPL, and RNFL were lower in group 2 in the final visit.
CONCLUSION: VDs and GCIPL thickness are useful parameters in the follow-up of MacTel type 2 disease in which microvascular changes are observed in parallel with neurodegeneration.

Keywords: nonproliferative macular telangiectasia, parafoveal vessel density, ganglion cell inner plexiform layer thickness

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