PURPOSE: To evaluate the vessel densities (VD) and ganglion cell inner plexiform layer (GCIPL) thicknesses in macular telangiectasia (MacTel) type 2.
METHODS: 36 eyes with MacTel type 2 and 30 controls were included in this prospective study. Based on the presence of ellipsoid zone (EZ) disruption two groups were formed: Group 1, MacTel eyes with intact EZ. Group 2; with EZ disruption.
RESULTS: In all MacTel eyes, a decrease was obtained in VDs and temporal parafoveal thickness at first year. (For group 1 p=0.006, p=0.045. For group 2 p=0.002, p= 0.02) The average and minimum GCIPL also decreased in group 2. (For average p=0.005, for minimum p=0.003) The mean VD, temporal and nasal thicknesses, average minimum GCIPL, and RNFL were lower in group 2 in the final visit.
CONCLUSION: VDs and GCIPL thickness are useful parameters in the follow-up of MacTel type 2 disease in which microvascular changes are observed in parallel with neurodegeneration.